Miscarriage Genetic Evaluation Test (Genetic Diagnosis of Miscarriages) – iMGE Test™ is a group of analyses of the miscarriage material performed with molecular biology techniques which allow to obtain information on the presence of chromosomal defects and about the sex of the fetus.
In contrast to classical cytogenetic methods:
Figure 1. Without the chromosome analysis is a group
Figure 2. With the chromosome analysis
Figure 3. With the chromosome analysis based on NGS technique
|iMGE XY Test||iMGE+ Test||iMGE 24 Test|
|Scope||X, Y chromosomes (odentification of sex)||chromosome|
13, 15, 16, 18, 21, 22; X and Y chromosomes
Polymerase chain reaction
|QF-PCR Quantitative Fluorescence Polymerase Chain Reaction||NGS Next Generation Sequencing|
|Reading||2 places of AMELY and SRY on X and Y chromosome||42 places on 8 chromosomes||100 000 places on all chromosomes|
In the case of miscarriage, testing for genetic conditions should be routinely conducted in order to determine the probable cause of pregnancy loss.
iMGE Tests is recommended in particular if miscarriage occurs in:
If the genetic causes of miscarriage are identified, the following actions are recommended:
This test was designed to detect aneuploidies and imbalance resulting from Robertsonian translocations. It does not detect segmental aneuploidies, germline mosaicism related to aneuploidy, structural chromosome defects (e.g. deletion of the chromosome part, inversion, duplication), uniparental disomy, triploidy, tetraploidy.