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Next Generation IVF
What would you say if we gave you a tool that dramatically increase your clinic’s IVF success rate?
Preimplantation Genetic Diagnosis (PGD) has originally been based on following techniques: FISH – 1 read per chromosome, QF- PCR – several reads per chromosome, aCGH – 200 reads per chromosome. Next Generation Sequencing (NGS), the newest form of sequencing, is being introduced into PGD procedures in IVF laboratories all over the world. NGS (Next Generation Sequencing) is the most trustworthy approach available on the market with more then 100 000 reads per chromosome. INVICTA has been the first in the world to introduce NGS-based PGD into its clinical practice and is currently offering NGS-based PGD laboratory services to others.
Molecular genetics tools available so far for IVF laboratories conducting PGD offered restricted number of reads from region of interest. Consequently this limitation made specificity of PGS results questionable and purposefulness of PGS debatable.
Introduction of aCGH techniques in IVF clinics meant that the range of analysis was extended to all chromosomes, but it did not improve the reliability. A direct sequencing is a reference method for all techniques of genetic information read-out. Although Sanger sequencing has been a gold standard for more than 3 decades it is now being replaced by its successor: Next Generation Sequencing.
NGS as a powerful technique involving massive parallel sequencing approach that provides information derived from the abundant reads of every region of interest. NGS has become a trendsetter for all scientific and molecular diagnostic applications. Now, also in IVF field, NGS is becoming available for the IVF laboratories and their patients. PGS NGS 360oTM is INVICTA’s product bringing the trustworthiness of PGD to a whole new level.
PGS NGS 360oTM is opening a new era of Next Generation IVF.
