Invicta is a leader among IVF clinics in Poland and has been offering preimplantation genetic diagnosis and screening to examine embryos conceived in routine in vitro fertilization cases since 2005. In 2013 Invicta Genetic Laboratory adopted powerful next-generation sequencing technology to diagnose in more reliable and trustful manner – with increased throughput, higher accuracy, and the simplest workflow from sample preparation through to data analysis. Our experts, using this innovative method, can perform simultaneously testing of embryo chromosomes for aneuploidies, translocation or sequence mutation – the methodology of procedure is adapted to the patient’s needs.
Invicta Genetic Laboratory has over 10 years of experience in the area of complex DNA testing. Year by year, our nationally and internationally trained specialists are developing procedures to best serve our patients using the finest tools for genetic diagnosis of embryos. One of the most important steps in the development of our laboratory practice was introduction of the newest technology – next-generation sequencing.
The Ion Personal Genome MachineTM (PGM) system is the combination of semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data. There is no need to use optics, modified bases, enzymatic cascades, chemiluminescence, or fluorescence. Instead, sequencer measures the H+ ions released during base incorporation. A principal component of the PGM is the sequencing chip, which is build of >1 million microwells connected to the ion sensor. During reaction each well contains a different DNA template, allowing massively parallel sequencing. Using this technology we obtain a huge amount of data and after analysis we get high accurate and reliable results. Depending on the number of embryos being examined we can choose one of the three types of chips with different numbers of microwells. Thanks to this solution all embryos from one patient can be examinated together in one procedure.
Invicta Genetic Laboratory offers a wide range of genetic testing for couples wanting to start a family. Our services are backed by application of the highest quality standards, such as molecular barcoding of every sample as well as internal and external quality controls to maximize security of the procedures. We can personalize the approach to the patients’ specific needs with the choice of PGS-NGS 360°TM and/or PGD ONETM test. PGS-NGS 360°TM is the screening all autosomal chromosomes and sex chromosomes for aneuploidies, with the possibility of Robertsonian translocation diagnosis at the same time. PGD ONETM is a complex diagnosis available for every single gene disorder with a known background. Aneuploidy screening and diagnosis of monogenetic disease can be performed simultaneously, minimizing the number of necessary biopsies to a single one.
The application of NGS in reproductive genetics is reaching new heights. Invicta with its IVF Clinic and Genetic Laboratory is a leader in the world in performing preimplantation genetic screening and diagnosis. Using the most up-to-date technology our experts performed already 6182 preimplantation genetic diagnosis procedures. Thanks to the high skills of our specialists we take advantage of unprecedented diagnostic capabilities offering our patients complex and trustworthy DNA testing.